Prenatal phthalate exposure reduction through an integrated intervention strategy

Pregnancy represents a sensitive susceptibility window to phthalate esters (PAEs). In this study, we develop an intervention strategy for reducing the exposure of pregnant women phthalates. Thirty-five women, who initially underwent maternity examination, were recruited from ongoing longitudinal prospective prenatal cohort study. The integrates diet, lifestyle, and environmental factors. Participants encouraged modify their behaviors habits according at three different periods. Urine samples collected participants after antenatal examination every month, 8 months, measure ten PAE metabolites. Mono-(2-ethyl-5-hydroxyhexyl) (MEHHP), mono-n-butyl (MnBP), mono-(2-ethyl-5-oxohexyl) (MEOHP) declined significantly 1st intervention, while mono-isobutyl (MiBP) mono-methyl (MMP) noticeably decreased 2nd intervention. sum molar concentrations MEHP, MEHHP, MEOHP, MECPP reduced by 20 40% during subsequent addition, MEP, MnBP, MMP, MiBP as well metabolites also reduced. Our findings suggest that through written recommendations can effectively reduce burden phthalates pregnancy.